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EIA Kits

Please use the dropdown below to find out about EIA Kits available outside the
United States:

Choose a Product => CanAg AFP EIA CanAg CA125 EIA CanAg CA15-3 EIA CanAg CA19-9 EIA CanAg CA242 EIA CanAg CEA EIA CanAg Free PSA EIA CanAg NSE EIA CanAg ProGRP EIA CanAg PSA EIA CanAg S100 EIA CanAg S100BB EIA CanAg SCC EIA CanChek (Tumor Marker Control)

CanAg SCC EIA - Lung Cancer and Gynecological Cancer

Squamous cell carcinoma antigen (SCC ag) is a group of glycoproteins with molecular weight ~45 kDa, belonging to the family of serine/cysteineprotease inhibitors¹. The protein was originally isolated by Kato and coworkers from human squamous cell carcinoma tissue and shown to consist of at least 10 subfractions differing in isoelectric point². More recent studies have shown that SCC antigen is composed of two distinct but highly homologous gene products, SCCA1 and SCCA2 with different inhibitor specificities³.

SCC antigen is a serological marker of squamous cell carcinomas of the uterine cervix, vulva, lung, head & neck, and esophagus^4-6. In squamous cell carcinoma of the uterine cervix, pretreatment serum SCC ag may be used as an early stage prognostic factor⁷ and the use of pretreatment SCC ag has been suggested in order to select high-risk patients for adjuvant therapy⁴. Further, for patients with elevated levels of SCC ag before start of treatment, the profile of SCC ag correlates with the response to radio- and chemotherapy and measurement of SCC ag may thus be used for early detection of recurrent disease and to monitor the effect of therapy⁴.

Download our CanAg SCC product information:

Product Catalog
CANAG SCC EIA - FULL PACKAGE INSERT
CANAG SCC EIA - PRODUCT SHEET
CANAG SCC EIA - MATERIAL SAFETY DATA SHEET

Product no: 800-10 (Not for distribution in the United States)

References

1. Suminami Y., Kishi F., Sekiguchi K., Kato H. (1991) Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Biochem Biophys Res Commun 181, 51-58.
   
2. Kato H. and Torigoe T. (1977) Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma. Cancer 40, 1621-1628.
   
3. Schneider S.S., Schick C., Fish K.E., Miller E., Pena J.C., Treter S.D., Hui S.M., Silverman G.A. (1995) A serine protease inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci USA, 92, 3147-3151.
   
4. de Bruijn H.W.A., Duk J.M., van der Zee A.G.J., Pras E., Willemse P.H.B., Boonstra H., Hollema H., Mourits M.J.E., de Vries E.G.E., Aalders J.G. (1998) The Clinical Value of Squamous cell Carcinoma Antigen in Cancer of the Uterine Cervix. Tumor Biol 19, 505-516.
   
5. Vassiliakopoulos T., Troupis T., Sotiropoulou C., Zacharatos P., Katsaounou P., Parthenis D., Noussia O., Troupis G., Papiris S., Kittas C., Roussos C., Zakynthinos S., Gorgoulis V. (2001) Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer. Lung Cancer 32, 137-144.
   
6. Snyderman C.H., Dámico F., Wagner R., Eibling D.E. (1995) A Reappraisal of the Squamous Cell Carcinoma Antigen as a Tumor Marker in Head and Neck Cancer. Arch Otolaryngol Head Neck Surg 121, 1294-1297.
   
7. Duk J.M., Groenier K.H., de Bruijn H.W.A., Hollema H., ten Hoor K.A., van der Zee A.G.J., Aalders J.G. (1996) Pretreatment Serum Squamous cell Carcinoma Antigen: A Newly Identified Prognostic Factor in Early-Stage Cervical Carcinoma. J Clin Oncol 14, 111-118. 1997.