Fujirebio™ Diagnostics, Inc.

About Us News Distributors Careers Contact Us

>Home >Rest of World Home >Products & Services >Manual Kits EIA Kits

EIA Kits

Please use the dropdown below to find out about EIA Kits available outside the
United States:

Choose a Product => CanAg AFP EIA Choose a Product => CanAg AFP EIA CanAg CA125 EIA CanAg CA15-3 EIA CanAg CA19-9 EIA CanAg CA242 EIA CanAg CEA EIA CanAg Free PSA EIA CanAg NSE EIA CanAg ProGRP EIA CanAg PSA EIA CanAg S100 EIA CanAg SCC EIA CYFRA 21-1 EIA HE4 MESOMARK

CanAg FREE PSA EIA - Prostate Cancer

PSA is a 32 kDa single-chain, glycoprotein serine protease with a chymotrypsin-like specificity produced by the secretory epithelium of the prostate gland¹. PSA is normally secreted into the seminal fluid and plays a functional role in the cleavage of the seminal vesicle proteins and the liquefaction of the seminal coagulum². Only low levels of PSA are normally present in the blood stream, and increasing serum concentrations indicate prostatic pathology, including benign prostatic hyperplasia and cancer of the prostate. Determination of PSA is now widely used for detection and management of patients with prostatic cancer and considered as the superior serological marker for cancer of the prostate³.

PSA has been shown to form stable complexes with different antiproteases and the dominating portion of PSA in patient serum occurs in complex with α1-antichymotrypsin (PSA-ACT)⁴. However there are large variations in the relationship between Free PSA and PSA-ACT complex between different individuals. A number of studies have found that the proportion of Free PSA is higher in benign prostatic disease as compared to prostatic cancer^{4, 5}. The Free PSA EIA is an assay for specific determination of Free PSA without cross reactivity with PSA-ACT complex⁶.

Download our FREE PSA EIA product information:

CANAG FREE PSA EIA - FULL PACKAGE INSERT
CANAG FREE PSA EIA - MATERIAL SAFETY DATA SHEET

Find Instructions for Use in multiple languages.

Download the
Fujirebio Diagnostics
EIA Kit Catalogue

Product no: 350-10 (Not for distribution in the United States)

References

1. Wang MC, Valenzuela LA, Murphy GP, Chu TM (1979). Purification of a human prostate specific antigen. Invest Urol 17: 159 - 163.
2. Lilja H. (1985). A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J Clin Invest 76: 1899 - 1903.
   
3. Haese A., Becker C., Diamandis E., and Lilja H., (2002) Adenocarcinoma of the Prostate In: “Tumor Markers. Phusiology, Pathobiology, Technology, and Clinical applications”.
4. Lilja H., Christensson A, Dahlén U., Matikainen M-T, Nilsson O., Pettersson K., Lövgren T. (1991). Prostate-specific antigen in serum occurs predominantly in complex with a1-antichymotrypsin. Clin. Chem 37: 1618 - 1625.
5. Christensson A, Björk T., Nilsson O., Dahlén U., Matikainen MT, Cockett ATK, Abrahamsson PA, Lilja H. (1993). Serum prostate specific antigen complexed to a1-antichymotrypsin as an indicator of prostate cancer. J Urology 150: 100 - 105.
6. Nilsson O., Peter A. Andersson I., Nilsson K., Grundström B., and Karlsson B. Antigenic determinants of prostatespecific antigen (PSA) and development of assays specific for different forms of PSA. Br J Cancer 75(6):789-797, 1997.