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CanAg S100 EIA (RUO)

This product is available for Research Use Only and is not for use in diagnostic procedures.

S100 is a 20 kDa protein belonging to the S100/calmodulin/troponin C super family of EF-hand calcium-binding proteins. S100 was originally isolated from human brain and is considered a glial-cell specific protein1. Today, 20 monomers of the S100 family have been identified based on structural and functional similarities2, 3. Most of the S100 proteins exist as dimers and are expressed in a cell-specific manner. Two of the S100 monomers, designated S100A1 and S100B4 are highly conserved between species and are found as homodimers (BB) and heterodimers (A1B) in central nervous system glial cells and in certain peripheral cells (ie, Schwann cells, melanocytes, adipocytes, and chondrocytes)5.

Download our CanAg S100 product information:

CANAG S100 EIA (RUO) - FULL PACKAGE INSERT
CANAG S100 EIA - MATERIAL SAFETY DATA SHEET

Product no: 708-85

References
  1. Moore BW (1965) A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19:739-744.
  2. Zimmer DB et al., (1995) The S100 protein family history, function and expression. Brain Res Bull 37:417-429.
  3. Heizmann CW et al., (2002) S100 proteins: structure, functions and pathology. Front Biosci 7:1356-1368.
  4. Schafer BW et al. (1995) Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics 25:638-643.
  5. Takahashi K. et al., (1984) Immunohistochemical study on the distribution of Alpha and Beta subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch 45:385-396.